MRC CoRE in RND Output
Modulation of motor cortical theta and gamma oscillations using phase-targeted, closed-loop optogenetic stimulation of local excitatory and inhibitory neurons.
2026. Brain Stimul, 19(2):103034.
Papers for Timothy Denison
View Timothy Denison's Profile2026
MRC CoRE in RND Output
Marks VS, van Rheede JJ, Karantonis DM, Esteller R, Dinsmoor D, Fleming JE, Larson B, Desborough L, Single P, Raike RS, D’Haese P, Englot DJ, Lempka SF, North R, Poree L, Bikson M, Denison T
Principles of Physiologic Closed-Loop Controllers in Neuromodulation
2026. Neuromodulation: Technology at the Neural Interface, 29(5): 679-700.
MRC CoRE in RND Output
Kirby MM, van Rheede JJ, Marks VS, Dijk DJ, Denison T, Constandinou TG
Review: Circadian disruption, chronotherapy, and deep brain stimulation (DBS) in Parkinson’s disease (PD)
2026. npj Parkinsons Dis.
MRC CoRE in RND Output
Piper RJ, Fleming JE, van Rheede JJ, Marks VS, Landin K, Costache D, Hasegawa H, Selway R, Richardson H, Seunarine K, D'Arco F, Carter S, Arcaro C, Moeller F, Dehbi HM, Valentin A, Kaliakatsos M, Denison T, Tisdall MM
Feasibility and optimization of a novel, cranially-mounted deep brain stimulation device for children with epilepsy - the CADET Pilot study.
2026. Brain Stimul, 19(4):103149.
Kremen V, Sladky V, Gerla V, Cao Y, Mivalt F, St Louis EK, Bower MR, Brinkmann B, Miller K, Van Gompel J, Cook M, Denison T, Leyde K, Worrell G
Post-Ictal Sleep Changes in Human Focal Epilepsy.
2026. J Neurosci, 46(9).
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PMC12962774
MRC CoRE in RND Output
Causse AA, Curot J, Lopes-Dos-Santos V, Nunes-da-Silva R, Barron HC, Dornier V, Denuelle M, De Barros A, Sol J, Lotterie J, Lehongre K, Fernandez-Vidal S, Frazzini V, Navarro V, Valton L, Barbeau EJ, Denison T, Reddy L, Dupret D
A learning-evoked slow-oscillatory architecture paces population activity for offline reactivation across the human medial temporal lobe
2026. Neuron (ePub ahead of print).
MRC CoRE in RND Output
Dithering suppresses half-harmonic neural synchronisation to photic stimulation in humans.
2026. Brain Stimul, 19(3):103111.
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PMC13328066
Suppression of pathological oscillations with transcranial focused ultrasound in Parkinson’s disease
Nat Commun, Epub ahead of Print (2026)
2025
Guo X, Pogosyan A, Debarros J, He S, Wehmeyer L, Rodriguez Plazas FU, Wendt K, Yin Z, Raslan A, Hart T, Morgante F, Denison T, Pereira EA, Ashkan K, Wang S, Tan H
Flexible and stable cycle-by-cycle phase-locked deep brain stimulation system targeting brain oscillations in the management of movement disorders.
2025. Brain Stimul, 18(5):1705-1717.
Multi-level encoding of reward, effort, and choice across the frontal cortex and basal ganglia during cost-benefit decision-making.
2025. Cell Rep, 44(2):115209.
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PMC11860760
2024
van Rheede JJ, Alagapan S, Denison T, Riva-Posse P, Rozell CJ, Mayberg HS, Waters AC, Sharott A
Cortical signatures of sleep are altered following effective deep brain stimulation for depression
2024. Translational Psychiatry, 14(1), 103.
McHugh SB, Lopes-Dos-Santos V, Castelli M, Gava GP, Thompson SE, Tam SKE, Hartwich K, Perry B, Toth R, Denison T, Sharott A, Dupret D
Offline hippocampal reactivation during dentate spikes supports flexible memory.
2024. Neuron, 112(22):3768-3781.e8.
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PMC7616703
Evoked resonant neural activity long-term dynamics can be reproduced by a computational model with vesicle depletion.
2024. Neurobiol Dis, 199:106565.
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PMC11300885
Sermon JJ, Benjaber M, Duchet B, Anso J, Olaru M, Starr P, Denison T
1:2 entrainment is not a device-induced artefact, except when it is.
2024. Brain Stimul, 17(2):149-151.
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PMC7615995
van Rheede JJ, Alagapan S, Denison T, Riva-Posse P, Rozell CJ, Mayberg HS, Waters AC, Sharott A
Cortical signatures of sleep are altered following effective deep brain stimulation for depression.
2024. Transl Psychiatry, 14(1):103.
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PMC10879134
2023
Wendt K, Sorkhabi MM, O'Shea J, Denison T, van Rheede JJ
Influence of time of day on resting motor threshold in clinical TMS practice
2023. Clinical Neurophysiology, 155: 65-67.
Wendt K, Sorkhabi MM, Stagg CJ, Fleming MK, Denison T, O'Shea J
The effect of pulse shape in theta-burst stimulation: Monophasic vs biphasic TMS.
2023. Brain Stimul, 16(4):1178-1185.
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PMC10444700
Fleming JE, Pont Sanchis I, Lemmens O, Denison-Smith A, West TO, Denison T, Cagnan H
From dawn till dusk: Time-adaptive bayesian optimization for neurostimulation.
2023. PLoS Comput Biol, 19(12)e1011674.
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PMC10718444
He S, Baig F, Merla A, Torrecillos F, Perera A, Wiest C, Debarros J, Benjaber M, Hart MG, Ricciardi L, Morgante F, Hasegawa H, Samuel M, Edwards MJ, Denison T, Pogosyan A, Ashkan K, Pereira EA, Tan H
Beta-triggered adaptive deep brain stimulation during reaching movement in Parkinson's disease.
2023. Brain, 146(12):5015-5030.
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PMC10690014
Sub-harmonic entrainment of cortical gamma oscillations to deep brain stimulation in Parkinson's disease: Model based predictions and validation in three human subjects.
2023. Brain Stimul, 16(5):1412-1424.
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PMC10635843
How to entrain a selected neuronal rhythm but not others: open-loop dithered brain stimulation for selective entrainment.
2023. J Neural Eng, 20(2).
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PMC7614323
Wiest C, He S, Duchet B, Pogosyan A, Benjaber M, Denison T, Hasegawa H, Ashkan K, Baig F, Bertaina I, Morgante F, Pereira EA, Torrecillos F, Tan H
Evoked resonant neural activity in subthalamic local field potentials reflects basal ganglia network dynamics.
2023. Neurobiol Dis, 178:106019.
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PMC7614125
2022
Piper RJ, Richardson RM, Worrell G, Carmichael DW, Baldeweg T, Litt B, Denison T, Tisdall MM
Towards network-guided neuromodulation for epilepsy.
2022. Brain, 145(10):3347-3362.
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PMC9586548
Distributed brain co-processor for tracking spikes, seizures and behaviour during electrical brain stimulation.
2022. Brain Commun, 4(3):fcac115.
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PMC9217965
Deli A, Denison T, Green AL
Patent Application: Modulating wakefulness and arousal
2022. WO/2022/200814
van Rheede JJ, Feldmann LK, Busch JL, Fleming JE, Mathiopoulou V, Denison T, Sharott A, Kühn AA
Diurnal modulation of subthalamic beta oscillatory power in Parkinson's disease patients during deep brain stimulation.
2022. NPJ Parkinsons Dis, 8(1):88.
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PMC9270436
Zamora M, Toth R, Morgante F, Ottaway J, Gillbe T, Martin S, Lamb G, Noone T, Benjaber M, Nairac Z, Sehgal D, Constandinou TG, Herron J, Aziz TZ, Gillbe I, Green AL, Pereira EA, Denison T
DyNeuMo Mk-1: Design and pilot validation of an investigational motion-adaptive neurostimulator with integrated chronotherapy.
2022. Exp Neurol, 351:113977.
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PMC7612891
Fleming JE, Kremen V, Gilron R, Gregg NM, Zamora M, Dijk DJ, Starr P, Worrell G, Little S, Denison T
Embedding digital chronotherapy into bioelectronic medicines.
2022. iScience, 25(4):104028.
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PMC8933700
2021
Case Report: Embedding "Digital Chronotherapy" Into Medical Devices-A Canine Validation for Controlling Status Epilepticus Through Multi-Scale Rhythmic Brain Stimulation.
2021. Front Neurosci, 15:734265.
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PMC8498587
Denison T, Rogers DJ, Memarian Sorkhabi M
Patent Application: Generation of controllable magnetic stimuli
2021. WO/2021/176219
2020
Debarros J, Brown P, Tan H, Denison T
Patent Granted: Emulation of electrophysiological signals derived by stimulation of a body
2020. WO/2020/165591
2019
Emerging technologies for improved deep brain stimulation.
2019. Nat. Biotechnol., 37(9):1024-1033.
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PMC6877347
2017
Cagnan H, Pedrosa D, Little S, Pogosyan A, Cheeran B, Aziz TZ, Green AL, Fitzgerald J, Foltynie T, Limousin P, Zrinzo L, Hariz M, Friston KJ, Denison T, Brown P
Stimulating at the right time: phase-specific deep brain stimulation.
2017. Brain, 140(1):132-145.
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PMC5226063
2016
Vansteensel MJ, Pels EGM, Bleichner MG, Branco MP, Denison T, Freudenburg ZV, Gosselaar P, Leinders S, Ottens TH, Van Den Boom MA, Van Rijen PC, Aarnoutse EJ, Ramsey NF
Fully Implanted Brain-Computer Interface in a Locked-In Patient with ALS.
2016.N. Engl. J. Med., 375(21):2060-2066.
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PMC5326682
Capogrosso M, Milekovic T, Borton D, Wagner F, Moraud EM, Mignardot JB, Buse N, Gandar J, Barraud Q, Xing D, Rey E, Duis S, Jianzhong Y, Ko WK, Li Q, Detemple P, Denison T, Micera S, Bezard E, Bloch J, Courtine G
A brain-spine interface alleviating gait deficits after spinal cord injury in primates.
2016.Nature, 539(7628):284-288.
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PMC5108412
2014
Stypulkowski P, Stanslaski SR, Jensen RM, Denison T, Giftakis J
Brain stimulation for epilepsy--local and remote modulation of network excitability.
2014. Brain Stimul. 7(3):350-8
2012
Afshar P, Khambhati A, Stanslaski SR, Carlson D, Jensen RM, Linde D, Dani S, Lazarewicz M, Cong P, Giftakis J, Stypulkowski P, Denison T
A translational platform for prototyping closed-loop neuromodulation systems.
2012.Front Neural Circuits, 6():117.
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PMC3551193
Stanslaski SR, Afshar P, Cong P, Giftakis J, Stypulkowski P, Carlson D, Linde D, Ullestad D, Avestruz AT, Denison T
Design and validation of a fully implantable, chronic, closed-loop neuromodulation device with concurrent sensing and stimulation.
2012.IEEE Trans Neural Syst Rehabil Eng, 20(4):410-21.
2011
Rouse AG, Stanslaski SR, Cong P, Jensen RM, Afshar P, Ullestad D, Gupta R, Molnar GF, Moran DW, Denison T
A chronic generalized bi-directional brain-machine interface.
2011.J Neural Eng, 8(3):036018.
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PMC3146241
2007
Denison T, Consoer K, Santa W, Avestruz AT, Cooley J, Kelly A
A 2 μW 100 nV/rtHz Chopper-Stabilized Instrumentation Amplifier for Chronic Measurement of Neural Field Potentials
2007. IEEE J Solid-St Circ 42(12):2934-45