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Timothy Denison
Professor of Engineering Science, MRC CoRE Leadership Team
Career Path
2025
Leadership Team, MRC CoRE in Restorative Neural Dynamics
Research Themes
Tools (devices, software, algorithms)
Our research spans three themes: smart implants using closed-loop control for neurotherapies (supporting four clinical studies), non-invasive therapies advancing TMS and memory-reactivation headsets, and resource-limited neurotech developing deployable hardware and algorithms for global healthcare.
Approaches
Experimental Medicine
Active and completed trials (EPIONE, CADET, MINDS, SPARKS) advance experimental medicine by validating adaptive and simplified deep brain stimulation for pain, epilepsy, MSA, and Parkinson’s disease. These studies translate neuroengineering innovation into clinical therapies, bridging lab research and patient care.
Recent Papers
Suppression of pathological oscillations with transcranial focused ultrasound in Parkinson’s disease
Nat Commun, Epub ahead of Print (2026)
Flexible and stable cycle-by-cycle phase-locked deep brain stimulation system targeting brain oscillations in the management of movement disorders.
2025. Brain Stimul, 18(5):1705-1717.
Multi-level encoding of reward, effort, and choice across the frontal cortex and basal ganglia during cost-benefit decision-making.
2025. Cell Rep, 44(2):115209.
Free Full Text at Europe PMC
PMC11860760