Ashwini Oswal
Career Path
Leadership Team, MRC CoRE in Restorative Neural Dynamics
MRC Clinician Scientist
Completion of training in Neurology
DPhil in Neuroscience
MRCP
MBBS (UCL)
MA (Gonville & Caius College, Cambridge)
Research Themes
Targeting motor learning & execution
We are working on predicting pathological subthalamic nucleus (STN) beta activity before its onset, in order to develop algorithms that deliver deep brain stimulation proactively in order to prevent pathological bursts. We are also leveraging DBS device accelerometer signals to track physiological states for predictive control.
Mapping & rebalancing memory
We are using transcranial ultrasound (TUS) to enhance cholinergic outputs from the basal forebrain in Parkinson's disease dementia and dementia with Lewy bodies.
Understanding & Engineering sleeping brain
We have plans to deliver low frequency Deep Brain Stimulation (DBS) at night in patients with Parkinson's disease, in order to enhance memory and cognitive functions.
Physiomarkers
We are using sensing enabled Deep Brain Stimulation (DBS) devices, to identify neurophysiological biomarkers for optimising adaptive DBS.
Tools (devices, software, algorithms)
We are using sensing enabled Deep Brain Stimulation (DBS) devices, to identify neurophysiological biomarkers for optimising adaptive DBS.
Approaches
Experimental Medicine
Our research is primarily patient-facing and aims to elucidate the mechanistic links between neural dynamics and neurological symptoms, using these insights to inform device-based therapies.
Computational Modelling
We use computational approaches including machine learning algorithms, to understand the links between neural activity at short timescales and behaviour.
Biomedical Engineering
Our methods rely heavily biomedical engineering approaches.