Deep brain stimulation can suppress pathological synchronisation in parkinsonian patients.

Eusebio A
Thevathasan W
Doyle Gaynor L
Bye E
Foltynie T
Zrinzo L
Ashkan K
Aziz TZ
Brown P

Scientific Abstract

Although deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a highly effective therapeutic intervention in severe Parkinson's disease, its mechanism of action remains unclear. One possibility is that DBS suppresses local pathologically synchronised oscillatory activity.

Similar content

Preprint
Guo X, Pogosyan A, Debarros J, He S, Wehmeyer L, Plazas FR, Wendt K, Yin Z, Raslan A, Hart T, Morgante F, Denison T, Pereira EA, Ashkan K, Wang S, Tan H

Flexible and Stable Cycle-by-Cycle Phase-Locked Deep Brain Stimulation System Targeting Brain Oscillations in the Management of Movement Disorders

Deep brain stimulation can suppress pathological synchronisation in parkinsonian patients.

Eusebio A
Thevathasan W
Doyle Gaynor L
Bye E
Foltynie T
Zrinzo L
Ashkan K
Aziz TZ
Brown P

Scientific Abstract

Although deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a highly effective therapeutic intervention in severe Parkinson's disease, its mechanism of action remains unclear. One possibility is that DBS suppresses local pathologically synchronised oscillatory activity.

Citation

2011.J. Neurol. Neurosurg. Psychiatry, 82(5):569-73.

Free Full Text at Europe PMC

PMC3072048

Downloads

View PDF (1MB)

Similar content

Preprint
Guo X, Pogosyan A, Debarros J, He S, Wehmeyer L, Plazas FR, Wendt K, Yin Z, Raslan A, Hart T, Morgante F, Denison T, Pereira EA, Ashkan K, Wang S, Tan H

Flexible and Stable Cycle-by-Cycle Phase-Locked Deep Brain Stimulation System Targeting Brain Oscillations in the Management of Movement Disorders