Tisdall Group
The Tisdall Group is based at Great Ormond Street Hospital for Children, and the UCL Great Ormond Street Institute of Child Health.
Research Themes
Physiomarkers
As an adjunct to clinical care, we are implanting fine electrodes into the thalami of children undergoing recordings of their brains during seizures. These recordings allow us to investigate the role of the thalamus in their seizures at a personalised level and to explore their optimal targets for neuromodulation therapy.
Tools (devices, software, algorithms)
We are a clinical and research group based at Great Ormond Street Hospital and the UCL-Great Ormond Street Institute of Child Health who are working together to improve surgical treatments and outcomes for children with epilepsy. We are exploring the use of novel deep brain stimulation devices to treat children with drug resistant epilepsy.
Approaches
Computational Modelling
We are building models of brain networks using a range of imaging techniques including volumetry, diffusion MRI and resting fMRI. These models can be interrogated to provide prognostic information and therefore guide the choice of optimal patient and treatment modality.
Group Leader
Group Members
Recent Papers
Feasibility and optimization of a novel, cranially-mounted deep brain stimulation device for children with epilepsy - the CADET Pilot study.
Seizure and developmental outcomes following epilepsy surgery for children with Sturge-Weber syndrome.
Comparison of children and adults undergoing subdural grid electrode implantation or stereoelectroencephalography in a refractory epilepsy cohort from four European centers.
Determinants of intellectual and developmental outcomes in a multicenter pediatric hemispherotomy cohort.
Recent Preprints
Pilot Trial of the Picostim® Deep Brain Stimulation System for Children With Epilepsy: A Prospective, Open-Label Medical Device Study of a System Optimised for Paediatric Neuromodulation
A cardiac pulse signal affects local field potentials recorded from deep brain stimulation electrodes across clinical targets
A clinical grade neurostimulation implant for hierarchical control of physiological activity
A clinical grade neurostimulation implant for hierarchical control of physiological activity
Group Leader