MRC CoRE in Restorative Neural Dynamics

Andrews R, Fu B, Toomey CE, Breiter JC, Lachica J, Beckwith JS, Tian R, Brock EE, Needham L, Chant GJ, Loiseau C, Deconfin A, Baspin K, Popovic R, Evans J, Goh Y, Kurt B, Senicar L, Edmonds M, Bartels T, Bengoa-Vergniory N, Magill PJ, Jaunmuktane Z, Freeman OJ, Taylor BJ, Hardy J, Lashley T, Ryten M, Vendruscolo M, Wood NW, Weiss LE, Gandhi S, Lee SF

Large-scale visualization of α-synuclein oligomers in Parkinson's disease brain tissue.

2026. Nat Biomed Eng, 10(6):1222-1234.

Free Full Text at Europe PMC

PMC13278957

View PDF (4MB)

Malik MY, Guo F, Asif-Malik A, Eftychidis V, Barkas N, Eliseeva E, Timm KN, Wolska A, Bergin D, Zonta B, Ratz-Wirsching V, von Hörsten S, Walton ME, Magill PJ, Nerlov C, Minichiello L

Impaired striatal glutathione-ascorbate metabolism induces transient dopamine increase and motor dysfunction.

2024. Nat Metab, 6(11):2100-2117.

Free Full Text at Europe PMC

PMC11599059

View PDF (15MB)

Stedehouder J, Roberts BM, Raina S, Bossi S, Liu AKL, Doig NM, McGerty K, Magill PJ, Parkkinen L, Cragg SJ

Rapid modulation of striatal cholinergic interneurons and dopamine release by satellite astrocytes.

2024. Nat Commun, 15(1):10017.

Free Full Text at Europe PMC

PMC11577008

View PDF (8MB)

Grennan I, Mallet N, Magill PJ, Cagnan H, Sharott A

Beta bursts in the parkinsonian cortico-basal ganglia network form spatially discrete ensembles.

2024. Neurobiol Dis, 201:106652.

Free Full Text at Europe PMC

PMC11496931

View PDF (10MB)

Avvisati R, Kaufmann AK, Young CJ, Portlock GE, Cancemi S, Costa RP, Magill PJ, Dodson PD

Distributional coding of associative learning in discrete populations of midbrain dopamine neurons.

2024. Cell Rep, 43(4):114080.

Free Full Text at Europe PMC

PMC7616095

View PDF (8MB)

Kondabolu K, Doig NM, Ayeko O, Khan B, Torres A, Calvigioni D, Meletis K, Koós T, Magill PJ

A Selective Projection from the Subthalamic Nucleus to Parvalbumin-Expressing Interneurons of the Striatum.

2023. eNeuro, 10(7).

Free Full Text at Europe PMC

PMC10327533

View PDF (6MB)

Wiest C, Torrecillos F, Pogosyan A, Bange M, Muthuraman M, Groppa S, Hulse N, Hasegawa H, Ashkan K, Baig F, Morgante F, Pereira EA, Mallet N, Magill PJ, Brown P, Sharott A, Tan H

The aperiodic exponent of subthalamic field potentials reflects excitation/inhibition balance in Parkinsonism.

2023. eLife, 12:e82467

Free Full Text at Europe PMC

PMC10005762

View PDF (2MB)

West TO, Magill PJ, Sharott A, Litvak V, Farmer SF, Cagnan H

Stimulating at the right time to recover network states in a model of the cortico-basal ganglia-thalamic circuit.

2022. PLoS Comput Biol, 18(3)e1009887.

Free Full Text at Europe PMC

PMC8939795

View PDF (4MB)

Nakamura KC, Sharott A, Tanaka T, Magill PJ

Input Zone-Selective Dysrhythmia in Motor Thalamus after Dopamine Depletion.

2021. J Neurosci, 41(50):10382-10404.

Free Full Text at Europe PMC

PMC8672689

View PDF (9MB)

Roberts BM, Doig NM, Brimblecombe KR, Lopes EF, Siddorn RE, Threlfell S, Connor-Robson N, Bengoa-Vergniory N, Pasternack N, Wade-Martins R, Magill PJ, Cragg SJ

GABA uptake transporters support dopamine release in dorsal striatum with maladaptive downregulation in a parkinsonism model.

2020. Nat. Commun., 11(1):4958.

Free Full Text at Europe PMC

PMC7532441

View PDF (4MB)

Kosillo P, Doig NM, Ahmed KM, Agopyan-Miu AHCW, Wong CD, Conyers L, Threlfell S, Magill PJ, Bateup HS

Tsc1-mTORC1 signaling controls striatal dopamine release and cognitive flexibility.

2019. Nat. Commun., 10(1):5426.

Free Full Text at Europe PMC

PMC6882901

View PDF (4MB)

Cagnan H, Mallet N, Moll CK, Gulberti A, Holt AB, Westphal M, Gerloff C, Engel AK, Hamel W, Magill PJ, Brown P, Sharott A

Temporal evolution of beta bursts in the parkinsonian cortical and basal ganglia network.

2019. Proc. Natl. Acad. Sci. U.S.A., 116:16095-16104.

Free Full Text at Europe PMC

PMC6690030

View PDF (2MB)

Reis C, Sharott A, Magill PJ, van Wijk B, Parr T, Zeidman P, Friston KJ, Cagnan H

Thalamocortical dynamics underlying spontaneous transitions in beta power in Parkinsonism.

2019. Neuroimage, 193:103-114.

Free Full Text at Europe PMC

PMC6503152

View PDF (2MB)

Trouche S, Koren V, Doig NM, Ellender TJ, El-Gaby M, Lopes-Dos-Santos V, Reeve HM, Perestenko PV, Garas FN, Magill PJ, Sharott A, Dupret D

A Hippocampus-Accumbens Tripartite Neuronal Motif Guides Appetitive Memory in Space.

2019. Cell, 176(6):1393-1406.e16.

Free Full Text at Europe PMC

PMC6424821

View PDF (10MB)

West TO, Berthouze L, Halliday DM, Litvak V, Sharott A, Magill PJ, Farmer SF

Propagation of beta/gamma rhythms in the cortico-basal ganglia circuits of the parkinsonian rat.

2018. J. Neurophysiol., 119(5):1608-1628.

Free Full Text at Europe PMC

PMC6008089

View PDF (6MB)

Garas FN, Kormann E, Shah RS, Vinciati F, Smith Y, Magill PJ, Sharott A

Structural and molecular heterogeneity of calretinin-expressing interneurons in the rodent and primate striatum.

2018. J. Comp. Neurol., 526(5):877-898.

Free Full Text at Europe PMC

PMC5814860

View PDF (3MB)

Sharott A, Vinciati F, Nakamura KC, Magill PJ

A Population of Indirect Pathway Striatal Projection Neurons Is Selectively Entrained to Parkinsonian Beta Oscillations.

2017. J. Neurosci., 37(41):9977-9998.

Free Full Text at Europe PMC

PMC5637121

View PDF (5MB)

Garas FN, Shah RS, Kormann E, Doig NM, Vinciati F, Nakamura KC, Dorst MC, Smith Y, Magill PJ, Sharott A

Secretagogin expression delineates functionally-specialized populations of striatal parvalbumin-containing interneurons.

2016. eLife, 5:e16088.

Free Full Text at Europe PMC

PMC5036963

View PDF (7MB)

Bogacz R, Martin Moraud E, Abdi A, Magill PJ, Baufreton J

Properties of Neurons in External Globus Pallidus Can Support Optimal Action Selection.

2016.PLoS Comput. Biol., 12(7):e1005004.

Free Full Text at Europe PMC

PMC4936724

View PDF (3MB)

Dodson PD, Dreyer JK, Jennings K, Syed EC, Wade-Martins R, Cragg SJ, Bolam JP, Magill PJ

Representation of spontaneous movement by dopaminergic neurons is cell-type selective and disrupted in parkinsonism.

2016. Proc. Natl. Acad. Sci. U.S.A., 113(15):E2180-8.

Free Full Text at Europe PMC

PMC4839395

View PDF (3MB)

Sloan M, Alegre-Abarrategui J, Potgieter D, Kaufmann AK, Exley R, Deltheil T, Threlfell S, Connor-Robson N, Brimblecombe KR, Wallings R, Cioroch M, Bannerman DM, Bolam JP, Magill PJ, Cragg SJ, Dodson PD, Wade-Martins R

LRRK2 BAC transgenic rats develop progressive, L-DOPA-responsive motor impairment, and deficits in dopamine circuit function.

2016.Hum. Mol. Genet., 25(5):951-63.

Free Full Text at Europe PMC

PMC4754049

View PDF (1MB)

Syed EC, Grima LL, Magill PJ, Bogacz R, Brown P, Walton ME

Action initiation shapes mesolimbic dopamine encoding of future rewards.

2016.Nat. Neurosci., 19(1):34-6.

Free Full Text at Europe PMC

PMC4697363

View PDF (1MB)

Pristerà A, Lin WY, Kaufmann AK, Brimblecombe KR, Threlfell S, Dodson PD, Magill PJ, Fernandes C, Cragg SJ, Ang SL

Transcription factors FOXA1 and FOXA2 maintain dopaminergic neuronal properties and control feeding behavior in adult mice.

2015.Proc. Natl. Acad. Sci. U.S.A., 112(35):E4929-38.

Free Full Text at Europe PMC

PMC4568236

View PDF (2MB)

Abdi A, Mallet N, Mohamed FY, Sharott A, Dodson PD, Nakamura KC, Suri S, Avery SV, Larvin JT, Garas FN, Garas SN, Vinciati F, Morin S, Bezard E, Baufreton J, Magill PJ

Prototypic and arkypallidal neurons in the dopamine-intact external globus pallidus.

2015. J. Neurosci., 35(17):6667-88.

Free Full Text at Europe PMC

PMC4412890

View PDF (6MB)

Dodson PD, Larvin JT, Duffell JM, Garas FN, Doig NM, Kessaris N, Duguid IC, Bogacz R, Butt SJ, Magill PJ

Distinct developmental origins manifest in the specialized encoding of movement by adult neurons of the external globus pallidus.

2015. Neuron, 86(2):501-13.

Free Full Text at Europe PMC

PMC4416107

View PDF (5MB)

Bienvenu TC, Busti D, Micklem BR, Mansouri M, Magill PJ, Ferraguti F, Capogna M

Large intercalated neurons of amygdala relay noxious sensory information.

2015.J. Neurosci., 35(5):2044-57.

Free Full Text at Europe PMC

PMC4315833

View PDF (6MB)

Nakamura KC, Sharott A, Magill PJ

Temporal coupling with cortex distinguishes spontaneous neuronal activities in identified basal ganglia-recipient and cerebellar-recipient zones of the motor thalamus.

2014.Cereb. Cortex, 24(1):81-97.

Free Full Text at Europe PMC

PMC3862266

View PDF (15MB)

Nevado-Holgado AJ, Mallet N, Magill PJ, Bogacz R

Effective connectivity of the subthalamic nucleus-globus pallidus network during Parkinsonian oscillations.

2014.J. Physiol. (Lond.), 592(7):1429-55.

Free Full Text at Europe PMC

PMC3979604

View PDF (2MB)

Henny P, Brown MT, Micklem BR, Magill PJ, Bolam JP

Stereological and ultrastructural quantification of the afferent synaptome of individual neurons.

2014.Brain Struct Funct, 219(2):631-40.

Free Full Text at Europe PMC

PMC3933745

View PDF (3MB)

Doig NM, Magill PJ, Apicella P, Bolam JP, Sharott A

Cortical and thalamic excitation mediate the multiphasic responses of striatal cholinergic interneurons to motivationally salient stimuli.

2014. J. Neurosci., 34(8):3101-17.

Free Full Text at Europe PMC

PMC3931511

View PDF (5MB)

Janezic S, Threlfell S, Dodson PD, Dowie MJ, Taylor TN, Potgieter D, Parkkinen L, Senior SL, Anwar S, Ryan B, Deltheil T, Kosillo P, Cioroch M, Wagner K, Ansorge O, Bannerman DM, Bolam JP, Magill PJ, Cragg SJ, Wade-Martins R

Deficits in dopaminergic transmission precede neuron loss and dysfunction in a new Parkinson model.

2013.Proc. Natl. Acad. Sci. U.S.A., 110(42):E4016-25.

Free Full Text at Europe PMC

PMC3801069

View PDF (4MB)

Henny P, Brown MT, Northrop A, Faunes M, Ungless MA, Magill PJ, Bolam JP

Structural correlates of heterogeneous in vivo activity of midbrain dopaminergic neurons.

2012.Nat. Neurosci., 15(4):613-9.

Free Full Text at Europe PMC

PMC4242968

View PDF (3MB)

Sharott A, Doig NM, Mallet N, Magill PJ

Relationships between the firing of identified striatal interneurons and spontaneous and driven cortical activities in vivo.

2012. J. Neurosci., 32(38):13221-36.

Free Full Text at Europe PMC

PMC4242971

View PDF (4MB)

Yamawaki N, Magill PJ, Woodhall GL, Hall SD, Stanford IM

Frequency selectivity and dopamine-dependence of plasticity at glutamatergic synapses in the subthalamic nucleus.

2012.Neuroscience, 203():1-11.

Free Full Text at Europe PMC

PMC4245479

View PDF (3MB)

Schiemann J, Schlaudraff F, Klose V, Bingmer M, Seino S, Magill PJ, Zaghloul KA, Schneider G, Liss B, Roeper J

K-ATP channels in dopamine substantia nigra neurons control bursting and novelty-induced exploration.

2012.Nat. Neurosci., 15(9):1272-80.

Free Full Text at Europe PMC

PMC4242970

View PDF (3MB)

Bienvenu TC, Busti D, Magill PJ, Ferraguti F, Capogna M

Cell-type-specific recruitment of amygdala interneurons to hippocampal theta rhythm and noxious stimuli in vivo.

2012.Neuron, 74(6):1059-74.

Free Full Text at Europe PMC

PMC3391683

View PDF (15MB)

Henny P, Brown MT, Northrop A, Faunes M, Ungless MA, Magill PJ, Bolam JP

Structural correlates of heterogeneous in vivo activity of midbrain dopaminergic neurons.

2012.Nat. Neurosci., 15(4):613-9.

Free Full Text at Europe PMC

PMC4242968

View PDF (3MB)

Mallet N, Micklem BR, Henny P, Brown MT, Williams C, Bolam JP, Nakamura KC, Magill PJ

Dichotomous organization of the external globus pallidus.

2012. Neuron, 74(6):1075-86.

Free Full Text at Europe PMC

PMC3407962

View PDF (6MB)

Moran RJ, Mallet N, Litvak V, Dolan RJ, Magill PJ, Friston KJ, Brown P

Alterations in brain connectivity underlying beta oscillations in Parkinsonism.

2011.PLoS Comput. Biol., 7(8):e1002124.

Free Full Text at Europe PMC

PMC3154892

View PDF (2MB)

Cruz AV, Mallet N, Magill PJ, Brown P, Averbeck BB

Effects of dopamine depletion on information flow between the subthalamic nucleus and external globus pallidus.

2011.J. Neurophysiol., 106(4):2012-23.

Free Full Text at Europe PMC

PMC3191831

View PDF (1MB)

Ros H, Magill PJ, Moss J, Bolam JP, Mena-Segovia J

Distinct types of non-cholinergic pedunculopontine neurons are differentially modulated during global brain states.

2010.Neuroscience, 170(1):78-91.

Free Full Text at Europe PMC

PMC4242969

View PDF (4MB)

Bolam JP, Brown MT, Moss J, Magill PJ

Basal Ganglia: Internal Organization

2009. , 2(): 97–104.

View PDF (4MB)

Magill PJ, Bolam JP

Patent Granted: Methods of neural centre location and electrode placement in the central nervous system

2009. US Patent number US7582062B2

View PDF (4MB)

Brown MT, Henny P, Bolam JP, Magill PJ

Activity of neurochemically heterogeneous dopaminergic neurons in the substantia nigra during spontaneous and driven changes in brain state.

2009.J. Neurosci., 29(9):2915-25.

Free Full Text at Europe PMC

PMC4262786

View PDF (1MB)

Baufreton J, Kirkham E, Atherton JF, Menard A, Magill PJ, Bolam JP, Bevan MD

Sparse but selective and potent synaptic transmission from the globus pallidus to the subthalamic nucleus.

2009.J. Neurophysiol., 102(1):532-45.

Free Full Text at Europe PMC

PMC2712268

View PDF (5MB)

Cruz AV, Mallet N, Magill PJ, Brown P, Averbeck BB

Effects of dopamine depletion on network entropy in the external globus pallidus.

2009.J. Neurophysiol., 102(2):1092-102.

Free Full Text at Europe PMC

PMC2724349

View PDF (6MB)

Mallet N, Pogosyan A, Sharott A, Csicsvari J, Bolam JP, Brown P, Magill PJ

Disrupted dopamine transmission and the emergence of exaggerated beta oscillations in subthalamic nucleus and cerebral cortex.

2008.J. Neurosci., 28(18):4795-806.

View PDF (2MB)

Mena-Segovia J, Sims HM, Magill PJ, Bolam JP

Cholinergic brainstem neurons modulate cortical gamma activity during slow oscillations.

2008.J. Physiol. (Lond.), 586(12):2947-60.

Free Full Text at Europe PMC

PMC2517196

View PDF (1MB)

Kaya AH, Vlamings R, Tan S, Lim LW, Magill PJ, Steinbusch HW, Visser-Vandewalle V, Sharp T, Temel Y

Increased electrical and metabolic activity in the dorsal raphe nucleus of Parkinsonian rats.

2008.Brain Res., 1221():93-7.

View PDF (1MB)

Mallet N, Pogosyan A, Márton LF, Bolam JP, Brown P, Magill PJ

Parkinsonian beta oscillations in the external globus pallidus and their relationship with subthalamic nucleus activity.

2008.J. Neurosci., 28(52):14245-58.

Free Full Text at Europe PMC

PMC4243385

View PDF (2MB)

Lacey CJ, Bolam JP, Magill PJ

Novel and distinct operational principles of intralaminar thalamic neurons and their striatal projections.

2007.J. Neurosci., 27(16):4374-84.

View PDF (1MB)

Sadek AR, Magill PJ, Bolam JP

A single-cell analysis of intrinsic connectivity in the rat globus pallidus.

2007.J. Neurosci., 27(24):6352-62.

View PDF (3MB)

Temel Y, Boothman LJ, Blokland A, Magill PJ, Steinbusch HW, Visser-Vandewalle V, Sharp T

Inhibition of 5-HT neuron activity and induction of depressive-like behavior by high-frequency stimulation of the subthalamic nucleus.

2007.Proc. Natl. Acad. Sci. U.S.A., 104(43):17087-92.

Free Full Text at Europe PMC

PMC2040465

View PDF (1MB)

Magill PJ, Pogosyan A, Sharott A, Csicsvari J, Bolam JP, Brown P

Changes in functional connectivity within the rat striatopallidal axis during global brain activation in vivo.

2006.J. Neurosci., 26(23):6318-29.

View PDF (3MB)

Magill PJ, Sharott A, Bolam JP, Brown P

Delayed synchronization of activity in cortex and subthalamic nucleus following cortical stimulation in the rat.

2006.J. Physiol. (Lond.), 574(Pt 3):929-46.

Free Full Text at Europe PMC

PMC1817747

View PDF (1MB)

Lacey CJ, Boyes J, Gerlach O, Chen L, Magill PJ, Bolam JP

GABA(B) receptors at glutamatergic synapses in the rat striatum.

2005.Neuroscience, 136(4):1083-95.

View PDF (2MB)

Boraud T, Brown P, Goldberg JA, Graybiel AM, Magill PJ

Oscillations in the basal ganglia: The good, the bad and the unexpected

2005. , (): .

View PDF (3MB)

Magill PJ, Sharott A, Harnack D, Kupsch A, Meissner W, Brown P

Coherent spike-wave oscillations in the cortex and subthalamic nucleus of the freely moving rat.

2005.Neuroscience, 132(3):659-64.

View PDF (1MB)

Sharott A, Magill PJ, Harnack D, Kupsch A, Meissner W, Brown P

Dopamine depletion increases the power and coherence of beta-oscillations in the cerebral cortex and subthalamic nucleus of the awake rat.

2005.Eur. J. Neurosci., 21(5):1413-22.

View PDF (1MB)

Sharott A, Magill PJ, Bolam JP, Brown P

Directional analysis of coherent oscillatory field potentials in the cerebral cortex and basal ganglia of the rat.

2005.J. Physiol. (Lond.), 562(Pt 3):951-63.

Free Full Text at Europe PMC

PMC1665537

View PDF (1MB)

Klausberger T, Márton LF, Baude A, Roberts JD, Magill PJ, Somogyi P

Spike timing of dendrite-targeting bistratified cells during hippocampal network oscillations in vivo.

2004.Nat. Neurosci., 7(1):41-7.

View PDF (3MB)

Mena-Segovia J, Bolam JP, Magill PJ

Pedunculopontine nucleus and basal ganglia: distant relatives or part of the same family?

2004.Trends Neurosci., 27(10):585-8.

View PDF (1MB)

Magill PJ, Sharott A, Bolam JP, Brown P

Brain state-dependency of coherent oscillatory activity in the cerebral cortex and basal ganglia of the rat.

2004.J. Neurophysiol., 92(4):2122-36.

View PDF (2MB)

Ungless MA, Magill PJ, Bolam JP

Uniform inhibition of dopamine neurons in the ventral tegmental area by aversive stimuli.

2004.Science, 303(5666):2040-2.

View PDF (1MB)

Magill PJ, Sharott A, Bevan MD, Brown P, Bolam JP

Synchronous unit activity and local field potentials evoked in the subthalamic nucleus by cortical stimulation.

2004.J. Neurophysiol., 92(2):700-14.

View PDF (1MB)

Klausberger T, Magill PJ, Márton LF, Roberts JD, Cobden PM, Buzsáki G, Somogyi P

Brain-state- and cell-type-specific firing of hippocampal interneurons in vivo.

2003.Nature, 421(6925):844-8.

View PDF (1MB)

Brown P, Kupsch A, Magill PJ, Sharott A, Harnack D, Meissner W

Oscillatory local field potentials recorded from the subthalamic nucleus of the alert rat.

2002.Exp. Neurol., 177(2):581-5.

View PDF (1MB)

Bevan MD, Magill PJ, Terman D, Bolam JP, Wilson CJ

Move to the rhythm: oscillations in the subthalamic nucleus-external globus pallidus network.

2002.Trends Neurosci., 25(10):525-31.

View PDF (1MB)

Bevan MD, Magill PJ, Hallworth NE, Bolam JP, Wilson CJ

Regulation of the timing and pattern of action potential generation in rat subthalamic neurons in vitro by GABA-A IPSPs.

2002.J. Neurophysiol., 87(3):1348-62.

View PDF (1MB)

Magill PJ, Bolam JP, Bevan MD

Dopamine regulates the impact of the cerebral cortex on the subthalamic nucleus-globus pallidus network.

2001.Neuroscience, 106(2):313-30.

View PDF (5MB)

Magill PJ, Bolam JP, Bevan MD

Relationship of activity in the subthalamic nucleus-globus pallidus network to cortical electroencephalogram.

2000.J. Neurosci., 20(2):820-33.

View PDF (2MB)

Bevan MD, Wilson CJ, Bolam JP, Magill PJ

Equilibrium potential of GABA(A) current and implications for rebound burst firing in rat subthalamic neurons in vitro.

2000.J. Neurophysiol., 83(5):3169-72.

View PDF (1MB)

Papers for Peter J. Magill

2026

Large-scale visualization of α-synuclein oligomers in Parkinson's disease brain tissue.

2024

Impaired striatal glutathione-ascorbate metabolism induces transient dopamine increase and motor dysfunction.

Rapid modulation of striatal cholinergic interneurons and dopamine release by satellite astrocytes.

Beta bursts in the parkinsonian cortico-basal ganglia network form spatially discrete ensembles.

Distributional coding of associative learning in discrete populations of midbrain dopamine neurons.

2023

A Selective Projection from the Subthalamic Nucleus to Parvalbumin-Expressing Interneurons of the Striatum.

The aperiodic exponent of subthalamic field potentials reflects excitation/inhibition balance in Parkinsonism.

2022

Stimulating at the right time to recover network states in a model of the cortico-basal ganglia-thalamic circuit.

2021

Input Zone-Selective Dysrhythmia in Motor Thalamus after Dopamine Depletion.

2020

GABA uptake transporters support dopamine release in dorsal striatum with maladaptive downregulation in a parkinsonism model.

2019

Tsc1-mTORC1 signaling controls striatal dopamine release and cognitive flexibility.

Temporal evolution of beta bursts in the parkinsonian cortical and basal ganglia network.

Thalamocortical dynamics underlying spontaneous transitions in beta power in Parkinsonism.

A Hippocampus-Accumbens Tripartite Neuronal Motif Guides Appetitive Memory in Space.

2018

Propagation of beta/gamma rhythms in the cortico-basal ganglia circuits of the parkinsonian rat.

Structural and molecular heterogeneity of calretinin-expressing interneurons in the rodent and primate striatum.

2017

A Population of Indirect Pathway Striatal Projection Neurons Is Selectively Entrained to Parkinsonian Beta Oscillations.

2016

Secretagogin expression delineates functionally-specialized populations of striatal parvalbumin-containing interneurons.

Properties of Neurons in External Globus Pallidus Can Support Optimal Action Selection.

Representation of spontaneous movement by dopaminergic neurons is cell-type selective and disrupted in parkinsonism.

LRRK2 BAC transgenic rats develop progressive, L-DOPA-responsive motor impairment, and deficits in dopamine circuit function.

Action initiation shapes mesolimbic dopamine encoding of future rewards.

2015

Transcription factors FOXA1 and FOXA2 maintain dopaminergic neuronal properties and control feeding behavior in adult mice.

Prototypic and arkypallidal neurons in the dopamine-intact external globus pallidus.

Distinct developmental origins manifest in the specialized encoding of movement by adult neurons of the external globus pallidus.

Large intercalated neurons of amygdala relay noxious sensory information.

2014

Temporal coupling with cortex distinguishes spontaneous neuronal activities in identified basal ganglia-recipient and cerebellar-recipient zones of the motor thalamus.

Effective connectivity of the subthalamic nucleus-globus pallidus network during Parkinsonian oscillations.

Stereological and ultrastructural quantification of the afferent synaptome of individual neurons.

Cortical and thalamic excitation mediate the multiphasic responses of striatal cholinergic interneurons to motivationally salient stimuli.

2013

Deficits in dopaminergic transmission precede neuron loss and dysfunction in a new Parkinson model.

2012

Structural correlates of heterogeneous in vivo activity of midbrain dopaminergic neurons.

Relationships between the firing of identified striatal interneurons and spontaneous and driven cortical activities in vivo.

Frequency selectivity and dopamine-dependence of plasticity at glutamatergic synapses in the subthalamic nucleus.

K-ATP channels in dopamine substantia nigra neurons control bursting and novelty-induced exploration.

Cell-type-specific recruitment of amygdala interneurons to hippocampal theta rhythm and noxious stimuli in vivo.

Structural correlates of heterogeneous in vivo activity of midbrain dopaminergic neurons.

Dichotomous organization of the external globus pallidus.

2011

Alterations in brain connectivity underlying beta oscillations in Parkinsonism.

Effects of dopamine depletion on information flow between the subthalamic nucleus and external globus pallidus.

2010

Distinct types of non-cholinergic pedunculopontine neurons are differentially modulated during global brain states.

2009

Basal Ganglia: Internal Organization

Patent Granted: Methods of neural centre location and electrode placement in the central nervous system

Activity of neurochemically heterogeneous dopaminergic neurons in the substantia nigra during spontaneous and driven changes in brain state.

Sparse but selective and potent synaptic transmission from the globus pallidus to the subthalamic nucleus.

Effects of dopamine depletion on network entropy in the external globus pallidus.

2008

Disrupted dopamine transmission and the emergence of exaggerated beta oscillations in subthalamic nucleus and cerebral cortex.

Cholinergic brainstem neurons modulate cortical gamma activity during slow oscillations.

Increased electrical and metabolic activity in the dorsal raphe nucleus of Parkinsonian rats.

Parkinsonian beta oscillations in the external globus pallidus and their relationship with subthalamic nucleus activity.

2007

Novel and distinct operational principles of intralaminar thalamic neurons and their striatal projections.

A single-cell analysis of intrinsic connectivity in the rat globus pallidus.

Inhibition of 5-HT neuron activity and induction of depressive-like behavior by high-frequency stimulation of the subthalamic nucleus.

2006

Changes in functional connectivity within the rat striatopallidal axis during global brain activation in vivo.

Delayed synchronization of activity in cortex and subthalamic nucleus following cortical stimulation in the rat.

2005

GABA(B) receptors at glutamatergic synapses in the rat striatum.

Oscillations in the basal ganglia: The good, the bad and the unexpected

Coherent spike-wave oscillations in the cortex and subthalamic nucleus of the freely moving rat.