What are we measuring with GABA magnetic resonance spectroscopy?
Scientific Abstract
A number of recent papers1-3 have demonstrated a relationship between in vivo concentration of GABA, as assessed using Magnetic Resonance Spectroscopy (MRS), and an individual's task performance, giving a unique insight into the relationship between physiology and behavior. However, interpretation of the functional significance of the MRS GABA measure is not straightforward. Here we discuss some of the outstanding questions as to how total concentration of GABA within a cortical region relates to phasic and tonic GABA activity within the cortical volume studied.
Similar content
Preprint
Repeated unilateral handgrip contractions alter functional connectivity and improve contralateral limb response times: A neuroimaging study
Preprint
The effects of varying intensities of unilateral handgrip fatigue on bilateral movement
Paper
The Effects of Theta-Gamma Peak Stimulation on Sensorimotor Learning During Speech Production
2025. Neurobiology of Language, 6.
Paper
Baclofen, a GABAb receptor agonist, impairs motor learning in healthy people and changes inhibitory dynamics in motor areas.
2025. Imaging Neurosci (Camb), 3.
Free Full Text at Europe PMC