Memories reactivate during sleep, however the properties of such reactivation and its relationship to subsequent memory performance are not well understood. Here, we set out to examine memory reactivations associated with a serial reaction time task (SRTT). 48 human participants performed the SRTT and then slept in the lab while we deliberately induced reactivation in Slow Wave Sleep (SWS) using a Targeted Memory Reactivation (TMR) design. We detected reactivation after TMR cues using multiclass classification that adapted to sleep data by using sleep activity for training and wake activity for testing. We then examined the temporal properties of reactivation in relation to behavioral performance and sleep spindles. The observed reactivation was 3 to 20 times faster than waking activity. Finally, reactivation was more frequently observed in trials with high sigma power, supporting the idea that sleep spindles are associated with memory reactivation during sleep. These findings bring us closer to understanding the characteristics of human memory reactivation after TMR and provide evidence for the positive relationship between the detectability of reactivation and memory consolidation.