Intrinsic Neural Excitability Biases Allocation and Overlap of Memory Engrams.

Delamare G
Tomé DF

Scientific Abstract

Memories are thought to be stored in neural ensembles known as engrams that are specifically reactivated during memory recall. Recent studies have found that memory engrams of two events that happened close in time tend to overlap in the hippocampus and the amygdala, and these overlaps have been shown to support memory linking. It has been hypothesized that engram overlaps arise from the mechanisms that regulate memory allocation itself, involving neural excitability, but the exact process remains unclear. Indeed, most theoretical studies focus on synaptic plasticity and little is known about the role of intrinsic plasticity, which could be mediated by neural excitability and serve as a complementary mechanism for forming memory engrams. Here, we developed a rate-based recurrent neural network that includes both synaptic plasticity and neural excitability. We obtained structural and functional overlap of memory engrams for contexts that are presented close in time, consistent with experimental and computational studies. We then investigated the role of excitability in memory allocation at the network level and unveiled competitive mechanisms driven by inhibition. This work suggests mechanisms underlying the role of intrinsic excitability in memory allocation and linking, and yields predictions regarding the formation and the overlap of memory engrams.

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Intrinsic Neural Excitability Biases Allocation and Overlap of Memory Engrams.

Delamare G
Tomé DF

Scientific Abstract

Memories are thought to be stored in neural ensembles known as engrams that are specifically reactivated during memory recall. Recent studies have found that memory engrams of two events that happened close in time tend to overlap in the hippocampus and the amygdala, and these overlaps have been shown to support memory linking. It has been hypothesized that engram overlaps arise from the mechanisms that regulate memory allocation itself, involving neural excitability, but the exact process remains unclear. Indeed, most theoretical studies focus on synaptic plasticity and little is known about the role of intrinsic plasticity, which could be mediated by neural excitability and serve as a complementary mechanism for forming memory engrams. Here, we developed a rate-based recurrent neural network that includes both synaptic plasticity and neural excitability. We obtained structural and functional overlap of memory engrams for contexts that are presented close in time, consistent with experimental and computational studies. We then investigated the role of excitability in memory allocation at the network level and unveiled competitive mechanisms driven by inhibition. This work suggests mechanisms underlying the role of intrinsic excitability in memory allocation and linking, and yields predictions regarding the formation and the overlap of memory engrams.

Citation

2024. J Neurosci, 44(21).

DOI

10.1523/JNEUROSCI.0846-23.2024

Free Full Text at Europe PMC

PMC11112642

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Similar content

Preprint
Mederos S, Vissers N, Blakely P, Clopath C, Hofer SB

Overwriting an instinct: visual cortex instructs learning to suppress fear responses

Preprint
Delamare G, Zaki Y, Cai DJ, Clopath C

Drift of neural ensembles driven by slow fluctuations of intrinsic excitability

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Boboeva V, Pezzotta A, Clopath C, Akrami A

From recency to central tendency biases in working memory: a unifying network model