Impaired inhibitory processing: a new therapeutic target for autism and psychosis?
Scientific Abstract
In the healthy brain, homeostatic balance between excitation and inhibition maintains neural stability. Reduced inhibition may explain shared symptoms observed in autism and psychosis. Here we review evidence suggesting that altered levels of gamma-aminobutyric acid (GABA) may underlie both disorders, providing a potential cross-diagnostic therapeutic target.
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Impaired inhibitory processing: a new therapeutic target for autism and psychosis?
Scientific Abstract
In the healthy brain, homeostatic balance between excitation and inhibition maintains neural stability. Reduced inhibition may explain shared symptoms observed in autism and psychosis. Here we review evidence suggesting that altered levels of gamma-aminobutyric acid (GABA) may underlie both disorders, providing a potential cross-diagnostic therapeutic target.
Citation
2021. Br J Psychiatry, 218(6):295-298.
DOI
10.1192/bjp.2020.163
Free Full Text at Europe PMC
PMC7612604Downloads
Similar content
Paper
How does curriculum learning influence cognitive map formation?
2026. eLife (reviewed preprint)
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Noradrenaline causes a spread of association in the hippocampal cognitive map
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A learning-evoked slow-oscillatory architecture paces population activity for offline reactivation across the human medial temporal lobe
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Free Full Text at Europe PMC
PMC12241591