Impaired inhibitory processing: a new therapeutic target for autism and psychosis?

Heinze K
Barron HC
Howes EK
Ramaswami M
Broome MR

Scientific Abstract

In the healthy brain, homeostatic balance between excitation and inhibition maintains neural stability. Reduced inhibition may explain shared symptoms observed in autism and psychosis. Here we review evidence suggesting that altered levels of gamma-aminobutyric acid (GABA) may underlie both disorders, providing a potential cross-diagnostic therapeutic target.

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Nandi T, Puonti O, Clarke WT, Nettekoven CR, Barron HC, Kolasinski J, Hanayik T, Hinson EL, Berrington A, Bachtiar V, Johnstone A, Winkler AM, Thielscher A, Johansen-Berg H, Stagg CJ

tDCS induced GABA change is associated with the simulated electric field in M1, an effect mediated by grey matter volume in the MRS voxel

10.1101/2022.04.27.489665
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Ekhtiari H, Ghobadi-Azbari P, Thielscher A, Antal A, Li LM, Shereen AD, Cabral-Calderin Y, Keeser D, Bergmann TO, Jamil A, Violante IR, Almeida J, Meinzer M, Siebner HR, Woods AJ, Stagg CJ, Abend R, Antonenko D, Auer T, Bächinger M, Baeken C, Barron HC, Chase HW, Crinion J, Datta A, Davis MH, Ebrahimi M, Esmaeilpour Z, Falcone B, Fiori V, Ghodratitoostani I, Gilam G, Grabner RH, Greenspan JD, Groen G, Hartwigsen G, Hauser TU, Herrmann CS, Juan CH, Krekelberg B, Lefebvre S, Liew SL, Madsen KH, Mahdavifar-Khayati R, Malmir N, Marangolo P, Martin AK, Meeker TJ, Ardabili HM, Moisa M, Momi D, Mulyana B, Opitz A, Orlov N, Ragert P, Ruff CC, Ruffini G, Ruttorf M, Sangchooli A, Schellhorn K, Schlaug G, Sehm B, Soleimani G, Tavakoli H, Thompson B, Timmann D, Tsuchiyagaito A, Ulrich M, Vosskuhl J, Weinrich CA, Zare-Bidoky M, Zhang X, Zoefel B, Nitsche MA, Bikson M

A Checklist for Assessing the Methodological Quality of Concurrent tES-fMRI Studies (ContES Checklist): A Consensus Study and Statement

10.1101/2020.12.23.20248579

Citation

2021. Br J Psychiatry, 218(6):295-298.

DOI

10.1192/bjp.2020.163

Free Full Text at Europe PMC

PMC7612604

Downloads

View PDF (https://www.mrcbndu.ox.ac.uk/sites/default/files/uploads/PMC7612604.pdf)

Related Group

Barron Group

Impaired inhibitory processing: a new therapeutic target for autism and psychosis?

Heinze K
Barron HC
Howes EK
Ramaswami M
Broome MR

Scientific Abstract

In the healthy brain, homeostatic balance between excitation and inhibition maintains neural stability. Reduced inhibition may explain shared symptoms observed in autism and psychosis. Here we review evidence suggesting that altered levels of gamma-aminobutyric acid (GABA) may underlie both disorders, providing a potential cross-diagnostic therapeutic target.

Citation

2021. Br J Psychiatry, 218(6):295-298.

DOI

10.1192/bjp.2020.163

Free Full Text at Europe PMC

PMC7612604

Downloads

View PDF (https://www.mrcbndu.ox.ac.uk/sites/default/files/uploads/PMC7612604.pdf)

Related Group

Barron Group

Similar content

Preprint
Nandi T, Puonti O, Clarke WT, Nettekoven CR, Barron HC, Kolasinski J, Hanayik T, Hinson EL, Berrington A, Bachtiar V, Johnstone A, Winkler AM, Thielscher A, Johansen-Berg H, Stagg CJ

tDCS induced GABA change is associated with the simulated electric field in M1, an effect mediated by grey matter volume in the MRS voxel

10.1101/2022.04.27.489665
Preprint
Ekhtiari H, Ghobadi-Azbari P, Thielscher A, Antal A, Li LM, Shereen AD, Cabral-Calderin Y, Keeser D, Bergmann TO, Jamil A, Violante IR, Almeida J, Meinzer M, Siebner HR, Woods AJ, Stagg CJ, Abend R, Antonenko D, Auer T, Bächinger M, Baeken C, Barron HC, Chase HW, Crinion J, Datta A, Davis MH, Ebrahimi M, Esmaeilpour Z, Falcone B, Fiori V, Ghodratitoostani I, Gilam G, Grabner RH, Greenspan JD, Groen G, Hartwigsen G, Hauser TU, Herrmann CS, Juan CH, Krekelberg B, Lefebvre S, Liew SL, Madsen KH, Mahdavifar-Khayati R, Malmir N, Marangolo P, Martin AK, Meeker TJ, Ardabili HM, Moisa M, Momi D, Mulyana B, Opitz A, Orlov N, Ragert P, Ruff CC, Ruffini G, Ruttorf M, Sangchooli A, Schellhorn K, Schlaug G, Sehm B, Soleimani G, Tavakoli H, Thompson B, Timmann D, Tsuchiyagaito A, Ulrich M, Vosskuhl J, Weinrich CA, Zare-Bidoky M, Zhang X, Zoefel B, Nitsche MA, Bikson M

A Checklist for Assessing the Methodological Quality of Concurrent tES-fMRI Studies (ContES Checklist): A Consensus Study and Statement

10.1101/2020.12.23.20248579