Integrating new memories into the hippocampal network activity space.
When the brain forms new memories, what happens to the other, older memories? Here, we report that in a part of the brain called the hippocampus, the flexible reorganisation of nerve cell activity representing existing memories allows for embedding of new memories.
Scientific Abstract
By investigating the topology of neuronal co-activity, we found that mnemonic information spans multiple operational axes in the mouse hippocampus network. High-activity principal cells form the core of each memory along a first axis, segregating spatial contexts and novelty. Low-activity cells join co-activity motifs across behavioral events and enable their crosstalk along two other axes. This reveals an organizational principle for continuous integration and interaction of hippocampal memories.
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DOI
10.1038/s41593-021-00804-w