Denison Group
The Denison Group is based at the Institute of Biomedical Engineering and the Brain Network Dynamics Unit, University of Oxford.
Research Themes
Tools (devices, software, algorithms)
Our research spans three themes: smart implants using closed-loop control for neurotherapies (supporting four clinical studies), non-invasive therapies advancing TMS and memory-reactivation headsets, and resource-limited neurotech developing deployable hardware and algorithms for global healthcare.
Approaches
Experimental Medicine
Active and completed trials (EPIONE, CADET, MINDS, SPARKS) advance experimental medicine by validating adaptive and simplified deep brain stimulation for pain, epilepsy, MSA, and Parkinson’s disease. These studies translate neuroengineering innovation into clinical therapies, bridging lab research and patient care.
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Recent Papers
MRC CoRE in RND Output
Modulation of motor cortical theta and gamma oscillations using phase-targeted, closed-loop optogenetic stimulation of local excitatory and inhibitory neurons.
2026. Brain Stimul, 19(2):103034.
MRC CoRE in RND Output
Principles of Physiologic Closed-Loop Controllers in Neuromodulation
2026. Neuromodulation: Technology at the Neural Interface, 29(5): 679-700.
MRC CoRE in RND Output
Review: Circadian disruption, chronotherapy, and deep brain stimulation (DBS) in Parkinson’s disease (PD)
2026. npj Parkinsons Dis.
MRC CoRE in RND Output
Feasibility and optimization of a novel, cranially-mounted deep brain stimulation device for children with epilepsy - the CADET Pilot study.
2026. Brain Stimul, 19(4):103149.
Recent Preprints
Review: Circadian Dysfunction, Chronotherapy, and Deep Brain Stimulation (DBS) in Parkinson’s Disease (PD)
Pilot Trial of the Picostim® Deep Brain Stimulation System for Children With Epilepsy: A Prospective, Open-Label Medical Device Study of a System Optimised for Paediatric Neuromodulation
A cardiac pulse signal affects local field potentials recorded from deep brain stimulation electrodes across clinical targets
Phase-targeted modulation of essential tremor with transcranial magnetic stimulation of motor cortex
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