Brain stimulation for epilepsy--local and remote modulation of network excitability.
Scientific Abstract
The use of Deep Brain Stimulation (DBS) as a potential therapy for treatment resistant epilepsy remains an area of active clinical investigation. We recently reported the first chronic evaluation of an implantable, clinical-grade system that permits concurrent stimulation and recording, in a large animal (ovine) model developed to study DBS for epilepsy.
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Brain stimulation for epilepsy--local and remote modulation of network excitability.
Scientific Abstract
The use of Deep Brain Stimulation (DBS) as a potential therapy for treatment resistant epilepsy remains an area of active clinical investigation. We recently reported the first chronic evaluation of an implantable, clinical-grade system that permits concurrent stimulation and recording, in a large animal (ovine) model developed to study DBS for epilepsy.
Citation
2014. Brain Stimul. 7(3):350-8
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Modulation of motor cortical theta and gamma oscillations using phase-targeted, closed-loop optogenetic stimulation of local excitatory and inhibitory neurons.
2026. Brain Stimul, 19(2):103034.
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A clinical grade neurostimulation implant for hierarchical control of physiological activity
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2023. Clinical Neurophysiology, 155: 65-67.
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Cortical signatures of sleep are altered following effective deep brain stimulation for depression
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